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Perhaps the gravest burden of affliction is to see oneself as alone. Paul knew the weight of being alone and he also knew the Lord was there. In the depths of loneliness he knew the Lord was present:

16 At my first defense no one came to stand by me, but all deserted me. May it not be charged against them!
17 But the Lord stood by me and strengthened me, so that through me the message might be fully proclaimed and all the Gentiles might hear it. So I was rescued from the lion’s mouth.
18 The Lord will rescue me from every evil deed and bring me safely into his heavenly kingdom. To him be the glory forever and ever. Amen.</
2 Tim. 4:16-18.

The Lord knowing our weakness, and knowing that he was sending his sheep among the wolves, left with a promise that he would not leave us alone:

19 Go therefore and make disciples of all nations, baptizing them in the name of the Father and of the Son and of the Holy Spirit,
20 teaching them to observe all that I have commanded you. And behold, I am with you always, to the end of the age.”

Matt. 28:19-20.

In fact, the Lord was so tender of his friends that he spoke much the Spirit, who would come to comfort them:

15 “If you love me, you will keep my commandments.
16 And I will ask the Father, and he will give you another Helper, to be with you forever,
17 even the Spirit of truth, whom the world cannot receive, because it neither sees him nor knows him. You know him, for he dwells with you and will be in you.

John 14:15-17. And:

1 “I have said all these things to you to keep you from falling away.
2 They will put you out of the synagogues. Indeed, the hour is coming when whoever kills you will think he is offering service to God.
3 And they will do these things because they have not known the Father, nor me.
4 But I have said these things to you, that when their hour comes you may remember that I told them to you. The Work of the Holy Spirit “I did not say these things to you from the beginning, because I was with you.
5 But now I am going to him who sent me, and none of you asks me, ‘Where are you going?’
6 But because I have said these things to you, sorrow has filled your heart.
7 Nevertheless, I tell you the truth: it is to your advantage that I go away, for if I do not go away, the Helper will not come to you. But if I go, I will send him to you.

John 16:1-7.

Thus Polhill rightly says that faith lays hold upon the promise of the Lord’s fellowship to gain grace to persevere through trial:

1. Faith must live upon the promises of God’s gracious presence: God tells his people, “That he will be with them in the fire and in the water,” (Isai. 43:2); that is, in all danger and calamities whatsoever; neither shall this presence be for a little time only, but constant and perpetual. “He will never leave them, nor forsake them,” (Heb. 13:5). This is a choice comfort to good men, that in tribulations they are not left alone, but God is with them

Edward Polhill,
A Preparation for Suffering in an Evil Day