From Thomas Manton’s sermon on 1 Thess. 5:17.

Since to pray “without ceasing” could misunderstood, Manton works the possibilities and then concludes

“This praying without ceasing is to be interpreted of the universality and the frequency of the return of the occasions and opportunities of prayer; and we may be said to do that without ceasing which we do very often. So that though the act of prayer be intermitted, the course of prayer should not be interrupted; for we are to pray at all times, in all conditions, and in all businesses and affairs.”

As for all times means at the least daily

“We need daily bread, daily pardon, daily strength against temptations. Yea, there seemeth to be a double standing occasion; every day in the morning for direction, in the evening for protection; as God appointed a morning and evening sacrifice: Num. 28:4,”

It is also in every condition in which we may find ourslef

“In all estates and conditions, afflicted and prosperous. In an adverse or afflicted estate: James 5:13, ‘Is any among you afflicted? let him pray.’ That gives vent to our sorrow, and turneth it into a spiritual channel. In a prosperous estate we are to pray that we may not forget God.”

And finally prayer is not to spiritual matters alone

“In every business, civil or sacred: ‘In all thy ways acknowledge him, and he shall direct thy paths,’ Prov. 3:6. In business secular. Abraham’s servant beggeth success in his errand: Gen. 24:12, ‘O Lord God of my master Abraham! I pray thee send me goodspeed this day.’ In matters sacred: 2 Thes. 3:5, ‘The Lord direct your heart into the love of God.’ So that a serious sensible christian seldom wanteth an errand to the throne of grace, and if we be not strangers to ourselves, we cannot be strangers to God.”